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Target
Bcl-2-like protein 1
Ligand
BDBM50589732
Substrate
n/a
Meas. Tech.
ChEMBL_2194219 (CHEMBL5106579)
Ki
>10000±n/a nM
Citation
 Drennen, B; Goodis, CC; Bowen, N; Yu, W; Vickers, G; Wilder, PT; MacKerell, AD; Fletcher, S Scaffold hopping from indoles to indazoles yields dual MCL-1/BCL-2 inhibitors from MCL-1 selective leads. RSC Med Chem 13:963-969 (2022) [PubMed]  Article
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM50589732
Synonyms:
CHEMBL5207619 | US11760752, Compound 39
Type:
Small organic molecule
Emp. Form.:
C35H28Cl2N6O6S
Mol. Mass.:
731.604
SMILES:
Cc1cc(Oc2ccc(Cn3nc4ccc(Cl)cc4c3C(=O)NS(=O)(=O)c3ccc(NCc4ccncc4)c(c3)[N+]([O-])=O)cc2)cc(C)c1Cl
Structure:
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