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Target
Melanocortin receptor 3
Ligand
BDBM50590046
Substrate
n/a
Meas. Tech.
ChEMBL_2194697 (CHEMBL5107057)
Ki
11±n/a nM
Citation
 White, AM; Dellsén, A; Larsson, N; Kaas, Q; Jansen, F; Plowright, AT; Knerr, L; Durek, T; Craik, DJ Late-Stage Functionalization with Cysteine Staples Generates Potent and Selective Melanocortin Receptor-1 Agonists. J Med Chem 65:12956-12969 (2022) [PubMed]  Article
Target
Name:
Melanocortin receptor 3
Synonyms:
MC3-R | MC3R | MC3R_HUMAN | Melanocortin MC3 | Melanocortin receptor (M3 and M4)
Type:
Enzyme
Mol. Mass.:
36044.86
Organism:
Homo sapiens (Human)
Description:
P41968
Residue:
323
Sequence:
MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG
  
Inhibitor
Name:
BDBM50590046
Synonyms:
CHEMBL5181812
Type:
Small organic molecule
Emp. Form.:
C232H316N74O45S4
Mol. Mass.:
4989.72
SMILES:
[H][C@]12CSc3nnc(SC[C@]([H])(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)CNC(=O)[C@H](CCCC)NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)c1CCC2C(COC(=O)NCCNC(=O)CCOCCOCCOCCOCCOCCC(=O)NCCNC(=O)OCC4C5CCc6c(CCC45)c4SC[C@]5([H])NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc7c[nH]c8ccccc78)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc7ccccc7)NC(=O)[C@H](Cc7cnc[nH]7)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@]([H])(CSc6nn4)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc4c[nH]c6ccccc46)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4cnc[nH]4)NC5=O)C2CCc31 |r|
Structure:
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