Reaction Details  Report a problem with these data
Target
Estrogen receptor beta
Ligand
BDBM50241408
Substrate
n/a
Meas. Tech.
ChEMBL_2198163 (CHEMBL5110679)
EC50
37±n/a nM
Citation
 Khan, MZI; Uzair, M; Nazli, A; Chen, JZ An overview on Estrogen receptors signaling and its ligands in breast cancer. Eur J Med Chem 241:0 (2022) [PubMed]  Article
Target
Name:
Estrogen receptor beta
Synonyms:
ER-beta | ESR2 | ESR2_HUMAN | ESTRB | Estradiol receptor beta (ERβ) | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | estrogen beta
Type:
Protein
Mol. Mass.:
59238.43
Organism:
Homo sapiens (Human)
Description:
Q92731
Residue:
530
Sequence:
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
  
Inhibitor
Name:
BDBM50241408
Synonyms:
(2S)-liquiritigenin | 7-HYDROXY-2-(4-HYDROXY-PHENYL)-CHROMAN-4-ONE | CHEMBL252642 | LIQUIRTIGENIN | Liquiritigenin
Type:
Small organic molecule
Emp. Form.:
C15H12O4
Mol. Mass.:
256.2534
SMILES:
Oc1ccc(cc1)[C@@H]1CC(=O)c2ccc(O)cc2O1 |r|
Structure:
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