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Target
Protein Wnt-3a
Ligand
BDBM50518788
Substrate
n/a
Meas. Tech.
ChEMBL_2204519 (CHEMBL5117227)
IC50
4.1±n/a nM
Citation
 Ai, Y; Sakamuru, S; Imler, G; Xia, M; Xue, F Improving the solubility and antileukemia activity of Wnt/?-catenin signaling inhibitors by disrupting molecular planarity. Bioorg Med Chem 69:0 (2022) [PubMed]  Article
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A | WNT3A_HUMAN
Type:
PROTEIN
Mol. Mass.:
39379.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469237
Residue:
352
Sequence:
MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM50518788
Synonyms:
CHEMBL4454905
Type:
Small organic molecule
Emp. Form.:
C20H17N5O
Mol. Mass.:
343.3819
SMILES:
Cc1c(nnn1-c1ccccc1C)C(=O)Nc1ccc2ccccc2n1
Structure:
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