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Target
Amine oxidase [flavin-containing] A
Ligand
BDBM50594083
Substrate
n/a
Meas. Tech.
ChEMBL_2210866 (CHEMBL5123815)
IC50
>100000±n/a nM
Citation
 Menna, M; Fiorentino, F; Marrocco, B; Lucidi, A; Tomassi, S; Cilli, D; Romanenghi, M; Cassandri, M; Pomella, S; Pezzella, M; Del Bufalo, D; Zeya Ansari, MS; Toma?evi?, N; Mladenovi?, M; Viviano, M; Sbardella, G; Rota, R; Trisciuoglio, D; Minucci, S; Mattevi, A; Rotili, D; Mai, A Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. Eur J Med Chem 237:0 (2022) [PubMed]  Article
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA)
Type:
Protein
Mol. Mass.:
59689.53
Organism:
Homo sapiens (Human)
Description:
P21397
Residue:
527
Sequence:
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
  
Inhibitor
Name:
BDBM50594083
Synonyms:
CHEMBL5179091
Type:
Small organic molecule
Emp. Form.:
C29H42N6O2
Mol. Mass.:
506.6828
SMILES:
COc1cc2nc(NCCCN(C)C)nc(NC3CCN(CCCc4ccccc4)CC3)c2cc1OC
Structure:
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