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Target
Mediator of RNA polymerase II transcription subunit 25
Ligand
BDBM50442875
Substrate
n/a
Meas. Tech.
ChEMBL_2212565 (CHEMBL5125514)
IC50
2300±n/a nM
Citation
 McCullough, BS; Wang, H; Barrios, AM Inhibitor Screen Identifies Covalent Inhibitors of the Protein Histidine Phosphatase PHPT1. ACS Med Chem Lett 13:1198-1201 (2022) [PubMed]  Article
Target
Name:
Mediator of RNA polymerase II transcription subunit 25
Synonyms:
ACID1 | ARC92 | Activator interaction domain-containing protein 1 | Activator-recruited cofactor 92 kDa component | MED25 | MED25_HUMAN | PTOV2
Type:
PROTEIN
Mol. Mass.:
78181.90
Organism:
Homo sapiens
Description:
ChEMBL_120708
Residue:
747
Sequence:
MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQSKQPVPLPPAAPSGATLSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASGATGQPQPQGTAQPPPGAPQGPPGAASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
  
Inhibitor
Name:
BDBM50442875
Synonyms:
NORSTICTIC ACID
Type:
Small organic molecule
Emp. Form.:
C18H12O9
Mol. Mass.:
372.2825
SMILES:
Cc1cc(O)c(C=O)c2Oc3c4C(O)OC(=O)c4c(O)c(C)c3OC(=O)c12
Structure:
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