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Target
Dual specificity mitogen-activated protein kinase kinase 7
Ligand
BDBM50594445
Substrate
n/a
Meas. Tech.
ChEMBL_2213042 (CHEMBL5125991)
EC50
265±n/a nM
Citation
 Gehrtz, P; Marom, S; Bührmann, M; Hardick, J; Kleinbölting, S; Shraga, A; Dubiella, C; Gabizon, R; Wiese, JN; Müller, MP; Cohen, G; Babaev, I; Shurrush, K; Avram, L; Resnick, E; Barr, H; Rauh, D; London, N Optimization of Covalent MKK7 Inhibitors  J Med Chem 65:10341-10356 (2022) [PubMed]  Article
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 7
Synonyms:
Dual specificity mitogen-activated protein kinase kinase 7 | Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) | JNKK2 | MAP2K7 | MEK7 | MKK7 | MP2K7_HUMAN | PRKMK7 | SKK4
Type:
Protein
Mol. Mass.:
47502.52
Organism:
Homo sapiens (Human)
Description:
O14733
Residue:
419
Sequence:
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
  
Inhibitor
Name:
BDBM50594445
Synonyms:
CHEMBL5195838
Type:
Small organic molecule
Emp. Form.:
C23H23F2N9O
Mol. Mass.:
479.4852
SMILES:
Nc1ncnc2n(nc(-c3cn(CC(F)(F)c4ccccc4)nn3)c12)[C@@H]1CCCN(C1)C(=O)C=C |r|
Structure:
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