Reaction Details  Report a problem with these data
Target
Ubiquitin-like modifier-activating enzyme 1
Ligand
BDBM50285607
Substrate
n/a
Meas. Tech.
ChEMBL_2214840 (CHEMBL5127972)
IC50
1500±n/a nM
Citation
 Liang, Q; Liu, M; Li, J; Tong, R; Hu, Y; Bai, L; Shi, J NAE modulators: A potential therapy for gastric carcinoma. Eur J Med Chem 231:0 (2022) [PubMed]  Article
Target
Name:
Ubiquitin-like modifier-activating enzyme 1
Synonyms:
6.2.1.45 | Sbx | Uba1 | Ube1 | Ube1ax | Ube1x | Ubiquitin-activating enzyme E1 | Ubiquitin-activating enzyme E1 X | Ubiquitin-like modifier-activating enzyme 1 X
Type:
PROTEIN
Mol. Mass.:
117792.48
Organism:
Mus musculus
Description:
ChEMBL_120682
Residue:
1058
Sequence:
MSSSPLSKKRRVSGPDPKPGSNCSPAQSALSEVSSVPTNGMAKNGSEADIDESLYSRQLYVLGHEAMKMLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTTQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVEDFLSSFQVVVLTNSPLEAQLRVGEFCHSRGIKLVVADTRGLFGQLFCDFGEEMVLTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARHGFETGDFVSFSEVQGMIQLNGCQPMEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKKISFKSLPASLVEPDFVMTDFAKYSRPAQLHIGFQALHQFCALHNQPPRPRNEEDATELVGLAQAVNARSPPSVKQNSLDEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPIMQWLYFDALECLPEDKEALTEEKCLPRQNRYDGQVAVFGSDFQEKLSKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEVVVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPYIQVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNIDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPAENVNQYLTDSKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWGDCVTWACHHWHTQYCNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNTLHLDYVMAAANLFAQTYGLTGSQDRAAVASLLQSVQVPEFTPKSGVKIHVSDQELQSANASVDDSRLEELKATLPSPDKLPGFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYDISPADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYKVVQGHQQLDSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEVQGLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVSRVSKRKLGRHVRALVLELCCNDESGEDVEVPYVRYTIR
  
Inhibitor
Name:
BDBM50285607
Synonyms:
MLN-4924 | MLN-4924003 | Pevonedistat
Type:
Small organic molecule
Emp. Form.:
C21H25N5O4S
Mol. Mass.:
443.519
SMILES:
[H][C@]1(O)C[C@@]([H])(C[C@@]1([H])COS(N)(=O)=O)n1ccc2c(N[C@@]3([H])CCc4ccccc34)ncnc12 |r|
Structure:
Search PDB for entries with ligand similarity: