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Target
Venus kinase receptor 2
Ligand
BDBM50293160
Substrate
n/a
Meas. Tech.
ChEMBL_2218200 (CHEMBL5131332)
Kd
3400±n/a nM
Citation
 Mathavan, I; Liu, LJ; Robinson, SW; El-Sakkary, N; Elatico, AJJ; Gomez, D; Nellas, R; Owens, RJ; Zuercher, W; Navratilova, I; Caffrey, CR; Beis, K Identification of Inhibitors of the  ACS Med Chem Lett 13:1715-1722 (2022) [PubMed]  Article
Target
Name:
Venus kinase receptor 2
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
186972.22
Organism:
Schistosoma mansoni
Description:
ChEMBL_120754
Residue:
1641
Sequence:
MYQRLVLVFSFLWIIDKNSCASGDGCFGLFEKLKWNGTFSFNNKVLTLRLEVTNNPEHWIVNYLFEILARERLGYTKIEFVLIEDSNISSSLKRLQCPNTQCLKLPEIHLNLLLWLPLDGNVKFWAKPSSVTDHGPLGPIRSWKLLTQSCYNKSHLRGNPNYTSLKYDCSSTVDTVSQNYSGYQTESVQNSDLLNNHSLLSGKSVTILDFELNSTCLRYNSYSIPPPPLCSTDTKSTSTNSYQYCYTESYQAVKVTWAKLRTAAPQIFQLASKMYMSHDELGELVHSALLDSNIDRQSTYKQVACRWLRQNPIKWKSWTVDWDKKLNLTVAGLFSMYGKWVLHGLDRVAQEAVNFVNADSDYFRNSEYALSLDVRNLTCEPDVVLSDYFKVLENAVNTRLIGSIAALCSDSIEAVVELANIRKQIIVSPTVGSARFLEQQQYHYFFRTVPSMTLANFILLRLFLVWGWHRIVVFRKSDHFFEPLLFQAKGIEIIANIEMDEQQLTYKLAKDTLEELKQQNSRIFVVEYDARGTYLILCAAYHEGMYFSAGYVWFLNPWLSDQWWSELVGRNTECNFSEMLNITSWTFTVGHQLLIGPMVHSFIPRTSEFMDSDSKSGNNSSGTPNRTSSEQIRRRRHVFAQSQTLEVPPVLSRTKHNPNPNDLGKSIFSDHSKRKLIKDPLHDYTVYTYDAVILLASAVVHLLRENPAAASALDHPDVSETLRTLVARTNFGYRFQTDNSTTGQSSEINELVPGINDDNFGVDAGFQLAGDYYGIRSQSPASASNLRFNDHNERIADYWLLKQRHLNTTVPIIMWSTKNYEKVHEQDQQQQSYDPFNHMISSNNMSNKYDWKTTNAPFLYDEFQKRMTERWLDHVNWHTLGGPPNDGSINEKNCTLSFLSNQLHMGCTGATVFVTVTVTVLVLLPLIVFAHFYYRRKLKEIENRTRKPFEELCTELADLDMPAENIVLNRRVGQGAFGLVFGGEAKKSDLWEAVAVKVINEKANYEGKIDFLSEAKLMRSLNHPNVVRLIGISLNPKASLYLIMELMLLGDLKTYLLSRRILAQRSPNHEDIRPSTLTQMSMDIGQGLAYLHSKHLIHRDIACRNCLVAADRTVKIGDFGLTRQAAKNTSEAYYRFTRKCELPIRWMSPEAVQFGVFSIQSDIWSFGITLYEIITFGVFPYNGLGDVEVVERVKRMEFSITEFLPPQALNTVVCELINHCCKHQWQHRPSSMNQVLEVLIAYPDCIRPFLTDDPPKPNTTIDSLPFQPTVDTCIISESAMTGLAAIDSVGGFRTIRSASTVAVPISSCSPSPVPLNLPDDNSDKYYGCEKRLSEQTNLRDSTLSNHHTIFDWSDNYTSHPYTDSSVHSKLIGFYQLPMFSDRQTLFPSVVTDESKELNIMSKSGESSSLPPVFNNYTTSFVTSVSNTINISTNVLFNLSTSPISTTPSYQSIDESSQLIMKSPELITDQYTYSTGNTLHIRKQKRSNTTHINNTTSNIPDELNNLLSDNQLKLSLDADSIMNIEESDRSHMLITEDKNSDKQFFIVPRNESHMFNVSSIPRNPIQTWNINCLRPTRSLINLTSVRYPKHYLQNNIKSEHYASVDHFSSITKHSDIHGSDLTLPPSLFTFISDSFLSGRKTV
  
Inhibitor
Name:
BDBM50293160
Synonyms:
4-(6-isopropoxypyrazolo[1,5-b]pyridazin-3-yl)-N-(4-(4-methylpiperazin-1-yl)phenyl)pyrimidin-2-amine | CHEMBL496162
Type:
Small organic molecule
Emp. Form.:
C24H28N8O
Mol. Mass.:
444.5321
SMILES:
CC(C)Oc1ccc2c(cnn2n1)-c1ccnc(Nc2ccc(cc2)N2CCN(C)CC2)n1
Structure:
Search PDB for entries with ligand similarity: