Reaction Details  Report a problem with these data
Target
P2X purinoceptor 4
Ligand
BDBM50596626
Substrate
n/a
Meas. Tech.
ChEMBL_2221595 (CHEMBL5134929)
IC50
1290±n/a nM
Citation
 Mahmood, A; Ali Shah, SJ; Iqbal, J Design and synthesis of adamantane-1-carbonyl thiourea derivatives as potent and selective inhibitors of h-P2X4 and h-P2X7 receptors: An Emerging therapeutic tool for treatment of inflammation and neurological disorders. Eur J Med Chem 231:0 (2022) [PubMed]  Article
Target
Name:
P2X purinoceptor 4
Synonyms:
ATP receptor | P2RX4 | P2RX4_HUMAN | P2X4 | Purinergic receptor | Purinergic, P2X4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43374.70
Organism:
Homo sapiens (Human)
Description:
Purinergic, P2X4 0 HUMAN::Q99571
Residue:
388
Sequence:
MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIPDATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYCMKKRLYYREKKYKYVEDYEQGLASELDQ
  
Inhibitor
Name:
BDBM50596626
Synonyms:
CHEMBL5175938
Type:
Small organic molecule
Emp. Form.:
C18H20ClN3O3S
Mol. Mass.:
393.888
SMILES:
[O-][N+](=O)c1ccc(Cl)c(NC(=S)NC(=O)C23CC4CC(CC(C4)C2)C3)c1 |TLB:22:21:24:18.17.16,22:17:24:21.23.20,THB:20:21:24.19.18:16,20:19:21.23.22:16|
Structure:
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