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Target
Toll-like receptor 8
Ligand
BDBM443496
Substrate
n/a
Meas. Tech.
ChEMBL_2222657 (CHEMBL5135991)
IC50
2.7±n/a nM
Citation
 Sreekantha, RK; Mussari, CP; Dodd, DS; Pasunoori, L; Hegde, S; Posy, SL; Critton, D; Ruepp, S; Subramanian, M; Salter-Cid, LM; Tagore, DM; Sarodaya, S; Dudhgaonkar, S; Poss, MA; Schieven, GL; Carter, PH; Macor, JE; Dyckman, AJ Identification of 2-Pyridinylindole-Based Dual Antagonists of Toll-like Receptors 7 and 8 (TLR7/8). ACS Med Chem Lett 13:812-818 (2022) [PubMed]  Article
Target
Name:
Toll-like receptor 8
Synonyms:
CD_antigen: CD288 | TLR8 | TLR8_HUMAN | TRL8
Type:
Enzyme
Mol. Mass.:
119828.77
Organism:
Homo sapiens (Human)
Description:
Q9NR97
Residue:
1041
Sequence:
MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRNVVLTENDSRYNNMYVDSIKQY
  
Inhibitor
Name:
BDBM443496
Synonyms:
US10660877, Example 73
Type:
Small organic molecule
Emp. Form.:
C22H26FN3
Mol. Mass.:
351.4603
SMILES:
CC(C)c1c([nH]c2cc(F)c(cc12)C1CCNCC1)-c1ccnc(C)c1
Structure:
Search PDB for entries with ligand similarity: