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Target
Estrogen receptor
Ligand
BDBM50175419
Substrate
n/a
Meas. Tech.
ChEMBL_326622 (CHEMBL863381)
IC50
24±n/a nM
Citation
 Chesworth, R; Wessel, MD; Heyden, L; Mangano, FM; Zawistoski, M; Gegnas, L; Galluzzo, D; Lefker, B; Cameron, KO; Tickner, J; Lu, B; Castleberry, TA; Petersen, DN; Brault, A; Perry, P; Ng, O; Owen, TA; Pan, L; Ke, HZ; Brown, TA; Thompson, DD; DaSilva-Jardine, P Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands. Bioorg Med Chem Lett 15:5562-6 (2005) [PubMed]  Article
Target
Name:
Estrogen receptor
Synonyms:
ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1
Type:
Protein
Mol. Mass.:
66230.44
Organism:
Homo sapiens (Human)
Description:
P03372
Residue:
595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
  
Inhibitor
Name:
BDBM50175419
Synonyms:
4-(2-phenyl-1H-indol-3-yl)phenol | CHEMBL371012
Type:
Small organic molecule
Emp. Form.:
C20H15NO
Mol. Mass.:
285.3392
SMILES:
Oc1ccc(cc1)-c1c([nH]c2ccccc12)-c1ccccc1
Structure:
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