Reaction Details  Report a problem with these data
Target
Vasopressin V2 receptor
Ligand
BDBM50600612
Substrate
n/a
Meas. Tech.
ChEMBL_2234600 (CHEMBL5148372)
Ki
35±n/a nM
Citation
 Cao, X; Wang, P; Yuan, H; Zhang, H; He, Y; Fu, K; Fang, Q; Liu, H; Su, L; Yin, L; Xu, P; Xie, Y; Xiong, X; Wang, J; Zhu, X; Guo, D Benzodiazepine Derivatives as Potent Vasopressin V J Med Chem 65:9295-9311 (2022) [PubMed]  Article
Target
Name:
Vasopressin V2 receptor
Synonyms:
ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
40295.28
Organism:
Homo sapiens (Human)
Description:
P30518
Residue:
371
Sequence:
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
  
Inhibitor
Name:
BDBM50600612
Synonyms:
CHEMBL5187046
Type:
Small organic molecule
Emp. Form.:
C36H37ClN4O3
Mol. Mass.:
609.157
SMILES:
Clc1ccc2N(CCCN3CCOCC3)CCCN(C(=O)c3ccc(NC(=O)c4ccccc4-c4ccccc4)cc3)c2c1
Structure:
Search PDB for entries with ligand similarity: