Reaction Details  Report a problem with these data
Target
Stromelysin-3
Ligand
BDBM50138684
Substrate
n/a
Meas. Tech.
ChEMBL_329827 (CHEMBL862790)
Ki
5±n/a nM
Citation
 Pirard, B; Matter, H Matrix metalloproteinase target family landscape: a chemometrical approach to ligand selectivity based on protein binding site analysis. J Med Chem 49:51-69 (2006) [PubMed]  Article
Target
Name:
Stromelysin-3
Synonyms:
MMP-11 | MMP11 | MMP11_HUMAN | Matrix metalloproteinase 11 | Matrix metalloproteinase-11 | SL-3 | ST3 | STMY3 | Stromelysin-3
Type:
PROTEIN
Mol. Mass.:
54592.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_850716
Residue:
488
Sequence:
MAPAAWLRSAAARALLPPMLLLLLQPPPLLARALPPDAHHLHAERRGPQPWHAALPSSPAPAPATQEAPRPASSLRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGCAEPANTFL
  
Inhibitor
Name:
BDBM50138684
Synonyms:
(1-Benzyloxycarbonylamino-2-phenyl-ethyl)-{2-[1-carbamoyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-5-phenyl-pentyl}-phosphinic acid | 2-((1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)carbamoyl)-5-phenylpentyl(1-(benzyloxycarbonyl)-2-phenylethyl)phosphinic acid | CHEMBL115774
Type:
Small organic molecule
Emp. Form.:
C39H43N4O6P
Mol. Mass.:
694.7557
SMILES:
NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CCCc1ccccc1)CP(O)(=O)C(Cc1ccccc1)NC(=O)OCc1ccccc1
Structure:
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