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Target
Matrix metalloproteinase-15
Ligand
BDBM50180601
Substrate
n/a
Meas. Tech.
ChEMBL_330172 (CHEMBL863525)
IC50
13940±n/a nM
Citation
 Ma, D; Jiang, Y; Chen, F; Gong, LK; Ding, K; Xu, Y; Wang, R; Ge, A; Ren, J; Li, J; Li, J; Ye, Q Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids. J Med Chem 49:456-8 (2006) [PubMed]  Article
Target
Name:
Matrix metalloproteinase-15
Synonyms:
MMP-15 | MMP15 | MMP15_HUMAN | MT-MMP 2 | MT2-MMP | MT2MMP | MTMMP2 | Matrix metalloproteinase 15 | Matrix metalloproteinase-15 | Membrane-type matrix metalloproteinase 2 | Membrane-type-2 matrix metalloproteinase | SMCP-2
Type:
PROTEIN
Mol. Mass.:
75814.08
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106793
Residue:
669
Sequence:
MGSDPSAPGRPGWTGSLLGDREEAARPRLLPLLLVLLGCLGLGVAAEDAEVHAENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDGDFDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRMEPGYPKSILRDFMGCQEHVEPGPRWPDVARPPFNPHGGAEPGADSAEGDVGDGDGDFGAGVNKDGGSRVVVQMEEVARTVNVVMVLVPLLLLLCVLGLTYALVQMQRKGAPRVLLYCKRSLQEWV
  
Inhibitor
Name:
BDBM50180601
Synonyms:
3-(4-(2-phenylethynyl)benzoyl)pentanoic acid | CHEMBL202875
Type:
Small organic molecule
Emp. Form.:
C20H18O3
Mol. Mass.:
306.3551
SMILES:
CCC(CC(O)=O)C(=O)c1ccc(cc1)C#Cc1ccccc1
Structure:
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