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Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM32203
Substrate
n/a
Meas. Tech.
ChEMBL_2236133 (CHEMBL5149905)
IC50
208000±n/a nM
Citation
 Park, E; Song, KH; Kim, D; Lee, M; Van Manh, N; Kim, H; Hong, KB; Lee, J; Song, JY; Kang, S 2-Amino-1,3,4-thiadiazoles as Glutaminyl Cyclases Inhibitors Increase Phagocytosis through Modification of CD47-SIRP? Checkpoint. ACS Med Chem Lett 13:1459-1467 (2022) [PubMed]  Article
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM32203
Synonyms:
8-quinolinol | CHEMBL310555 | US10005735, Table 1.7 | US9394254, 6 | cid_1923 | oxine | quinolin-8-ol
Type:
Small organic molecule
Emp. Form.:
C9H7NO
Mol. Mass.:
145.158
SMILES:
Oc1cccc2cccnc12
Structure:
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