Ki Summary

Reaction Details

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Target

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Ligand

BDBM50602498

Substrate

n/a

Meas. Tech.

ChEMBL_2241054 (CHEMBL5155264)

IC50

2.1±n/a nM

Citation

Mata, G; Miles, DH; Drew, SL; Fournier, J; Lawson, KV; Mailyan, AK; Sharif, EU; Yan, X; Beatty, JW; Banuelos, J; Chen, J; Ginn, E; Chen, A; Gerrick, KY; Pham, AT; Wong, K; Soni, D; Dhanota, P; Shaqfeh, SG; Meleza, C; Narasappa, N; Singh, H; Zhao, X; Jin, L; Schindler, U; Walters, MJ; Young, SW; Walker, NP; Leleti, MR; Powers, JP; Jeffrey, JL Design, Synthesis, and Structure-Activity Relationship Optimization of Pyrazolopyrimidine Amide Inhibitors of Phosphoinositide 3-Kinase ? (PI3K?). J Med Chem 65:1418-1444 (2022) [PubMed] Article

More Info.:

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Target

Name:

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Synonyms:

PI3-kinase p110 subunit gamma | PI3-kinase subunit p120-gamma | PI3Kgamma | PIK3CG | PK3CG_HUMAN | Phosphatidylinositol 4,5-biphosphate 3-kinase catalytic subunit gamma (PIK3CG) | Phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) | Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma (PI3K gamma) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma (PI3Kgamma) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3K gamma) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3K) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3Kgamma) | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Phosphoinositide 3-Kinase (PI3K), gamma Chain A | Phosphoinositide 3-kinases gamma (PI3K gamma) | Phosphoinositide-3-kinase (PI3K gamma) | p120-PI3K

Type:

Enzyme Subunit

Mol. Mass.:

126470.30

Organism:

Homo sapiens (Human)

Description:

P48736

Residue:

1102

Sequence:

MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA

Inhibitor

Name:

BDBM50602498

Synonyms:

CHEMBL5204993

Type:

Small organic molecule

Emp. Form.:

C28H32N6O4

Mol. Mass.:

516.5915

SMILES:

C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1ccn2nc(N)c(C(=O)N[C@H]3CC[C@@H](CC3)C(O)=O)c2n1 |r,wU:1.1,30.36,wD:27.29,(8.04,3.55,;7.27,2.22,;8.04,.88,;8.04,-.66,;9.37,.11,;5.73,2.22,;4.82,3.46,;3.36,2.99,;2.03,3.76,;.69,2.99,;.69,1.44,;2.03,.68,;2.03,-.86,;3.36,1.45,;4.82,.97,;5.22,-.52,;-.64,3.76,;-.64,5.29,;-1.96,6.06,;-3.29,5.29,;-4.76,5.77,;-5.66,4.52,;-7.2,4.52,;-4.76,3.27,;-5.53,1.94,;-7.07,1.94,;-4.76,.61,;-5.53,-.73,;-7.07,-.73,;-7.84,-2.06,;-7.07,-3.39,;-5.53,-3.39,;-4.76,-2.06,;-7.84,-4.73,;-9.37,-4.73,;-7.07,-6.06,;-3.29,3.75,;-1.96,2.99,)|

Structure: