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Target
Bifunctional epoxide hydrolase 2
Ligand
BDBM50379273
Substrate
n/a
Meas. Tech.
ChEMBL_2247138 (CHEMBL5161348)
IC50
>50000±n/a nM
Citation
 Codony, S; Pont, C; Griñán-Ferré, C; Di Pede-Mattatelli, A; Calvó-Tusell, C; Feixas, F; Osuna, S; Jarné-Ferrer, J; Naldi, M; Bartolini, M; Loza, MI; Brea, J; Pérez, B; Bartra, C; Sanfeliu, C; Juárez-Jiménez, J; Morisseau, C; Hammock, BD; Pallàs, M; Vázquez, S; Muñoz-Torrero, D Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease. J Med Chem 65:4909-4925 (2022) [PubMed]  Article
Target
Name:
Bifunctional epoxide hydrolase 2
Synonyms:
Eph2 | Ephx2 | Epoxide hydratase | HYES_MOUSE | Soluble epoxide hydrolase (sEH)
Type:
Enzyme
Mol. Mass.:
62512.06
Organism:
Mus musculus (Mouse)
Description:
P34914
Residue:
554
Sequence:
MALRVAAFDLDGVLALPSIAGAFRRSEEALALPRDFLLGAYQTEFPEGPTEQLMKGKITFSQWVPLMDESYRKSSKACGANLPENFSISQIFSQAMAARSINRPMLQAAIALKKKGFTTCIVTNNWLDDGDKRDSLAQMMCELSQHFDFLIESCQVGMIKPEPQIYNFLLDTLKAKPNEVVFLDDFGSNLKPARDMGMVTILVHNTASALRELEKVTGTQFPEAPLPVPCNPNDVSHGYVTVKPGIRLHFVEMGSGPALCLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSPPEIEEYAMELLCKEMVTFLDKLGIPQAVFIGHDWAGVMVWNMALFYPERVRAVASLNTPFMPPDPDVSPMKVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRASDETGFIAVHKATEIGGILVNTPEDPNLSKITTEEEIEFYIQQFKKTGFRGPLNWYRNTERNWKWSCKGLGRKILVPALMVTAEKDIVLRPEMSKNMEKWIPFLKRGHIEDCGHWTQIEKPTEVNQILIKWLQTEVQNPSVTSKI
  
Inhibitor
Name:
BDBM50379273
Synonyms:
CHEMBL1994202 | US9238626, (-)-Huprine Y HCl
Type:
Small organic molecule
Emp. Form.:
C17H17ClN2
Mol. Mass.:
284.783
SMILES:
CC1=C[C@H]2C[C@@H](C1)c1c(C2)nc2cc(Cl)ccc2c1N |t:1|
Structure:
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