Reaction Details  Report a problem with these data
Target
Proteasome subunit beta type-6
Ligand
BDBM50185620
Substrate
n/a
Meas. Tech.
ChEMBL_361598 (CHEMBL859726)
Ki
148000±n/a nM
Citation
 Basse, N; Papapostolou, D; Pagano, M; Reboud-Ravaux, M; Bernard, E; Felten, AS; Vanderesse, R Development of lipopeptides for inhibiting 20S proteasomes. Bioorg Med Chem Lett 16:3277-81 (2006) [PubMed]  Article
Target
Name:
Proteasome subunit beta type-6
Synonyms:
PRE7 | PRS3 | PSB6_YEAST | PTS1 | Proteasome component C5
Type:
PROTEIN
Mol. Mass.:
26868.74
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_361598
Residue:
241
Sequence:
MATIASEYSSEASNTPIEHQFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYGKRFFPYYVHTIIAGLDEDGKGAVYSFDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD
  
Inhibitor
Name:
BDBM50185620
Synonyms:
CHEMBL378655 | TVTFKF
Type:
Small organic molecule
Emp. Form.:
C37H55N7O9
Mol. Mass.:
741.8741
SMILES:
CC(C)[C@H](NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Structure:
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