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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50606594
Substrate
n/a
Meas. Tech.
ChEMBL_2260710 (CHEMBL5215721)
IC50
18330±n/a nM
Citation
 Ning, XL; Li, YZ; Huo, C; Deng, J; Gao, C; Zhu, KR; Wang, M; Wu, YX; Yu, JL; Ren, YL; Luo, ZY; Li, G; Chen, Y; Wang, SY; Peng, C; Yang, LL; Wang, ZY; Wu, Y; Qian, S; Li, GB X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease. J Med Chem 64:8303-8332 (2021) [PubMed]  Article
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Human
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50606594
Synonyms:
CHEMBL5220402
Type:
Small organic molecule
Emp. Form.:
C15H13BrClN3O
Mol. Mass.:
366.64
SMILES:
OCC(Nc1cc(Br)cc2[nH]ncc12)c1cccc(Cl)c1
Structure:
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