Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM474862
Substrate
n/a
Meas. Tech.
ChEMBL_2262720 (CHEMBL5217731)
IC50
37±n/a nM
Citation
Zhang, W; Wu, M; Vadlakonda, S; Juarez, L; Cheng, X; Muppa, S; Chintareddy, V; Vogeti, L; Kellogg-Yelder, D; Williams, J; Polach, K; Chen, X; Raman, K; Babu, YS; Kotian, P Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors. Bioorg Med Chem 74:0 (2022) [PubMed] Article
More Info.:
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA