Reaction Details  Report a problem with these data
Target
Sterol O-acyltransferase 2
Ligand
BDBM50193722
Substrate
n/a
Meas. Tech.
ChEMBL_424061 (CHEMBL855070)
IC50
41600±n/a nM
Citation
 Park, KH; Park, YD; Han, JM; Im, KR; Lee, BW; Jeong, IY; Jeong, TS; Lee, WS Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata. Bioorg Med Chem Lett 16:5580-3 (2006) [PubMed]  Article
Target
Name:
Sterol O-acyltransferase 2
Synonyms:
ACACT2 | ACAT-2 | ACAT2 | Acetyl-CoA acetyltransferase, cytosolic | Acetyl-CoA transferase-like protein | Acyl coenzyme A:cholesterol acyltransferase 2 | Cholesterol acyltransferase 2 | Cytosolic acetoacetyl-CoA thiolase | SOAT2 | SOAT2_HUMAN
Type:
Enzyme
Mol. Mass.:
59912.75
Organism:
Homo sapiens (Human)
Description:
O75908
Residue:
522
Sequence:
MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQLRELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTMLFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
  
Inhibitor
Name:
BDBM50193722
Synonyms:
4-(2,4-dimethylpent-3-en-2-yl)-1,6,7-trihydroxy-3-methyl-9H-xanthen-9-one | CHEMBL218383
Type:
Small organic molecule
Emp. Form.:
C21H22O5
Mol. Mass.:
354.3964
SMILES:
[#6]\[#6](-[#6])=[#6]/C([#6])([#6])c1c(-[#6])cc(-[#8])c2c1oc1cc(-[#8])c(-[#8])cc1c2=O
Structure:
Search PDB for entries with ligand similarity: