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Target
DNA oxidative demethylase ALKBH2
Ligand
BDBM50416763
Substrate
n/a
Meas. Tech.
ChEMBL_2269281
IC50
56400±n/a nM
Citation
 Perry, GS; Das, M; Woon, ECY Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets. J Med Chem 64:16974-17003 (2021) [PubMed]
Target
Name:
DNA oxidative demethylase ALKBH2
Synonyms:
1.14.11.33 | ABH2 | ALKB2_HUMAN | ALKBH2 | Alkylated DNA repair protein alkB homolog 2 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 | Oxy DC1
Type:
PROTEIN
Mol. Mass.:
29338.68
Organism:
Homo sapiens
Description:
ChEMBL_120703
Residue:
261
Sequence:
MDRFLVKGAQGGLLRKQEEQEPTGEEPAVLGGDKESTRKRPRREAPGNGGHSAGPSWRHIRAEGLDCSYTVLFGKAEADEIFQELEKEVEYFTGALARVQVFGKWHSVPRKQATYGDAGLTYTFSGLTLSPKPWIPVLERIRDHVSGVTGQTFNFVLINRYKDGCDHIGEHRDDERELAPGSPIASVSFGACRDFVFRHKDSRGKSPSRRVAVVRLPLAHGSLLMMNHPTNTHWYHSLPVRKKVLAPRVNLTFRKILLTKK
  
Inhibitor
Name:
BDBM50416763
Synonyms:
CHEMBL5282569
Type:
Small organic molecule
Emp. Form.:
C14H12N2O5S
Mol. Mass.:
320.32
SMILES:
Cc1ccccc1S(=O)(=O)NC(=O)c1cc(ccn1)C(O)=O
Structure:
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