Reaction Details  Report a problem with these data
Target
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
Ligand
BDBM50416768
Substrate
n/a
Meas. Tech.
ChEMBL_2269282
IC50
21200±n/a nM
Citation
 Perry, GS; Das, M; Woon, ECY Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets. J Med Chem 64:16974-17003 (2021) [PubMed]
Target
Name:
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
Synonyms:
ABH3 | ALKB3_HUMAN | ALKBH3 | Alkylated DNA repair protein alkB homolog 3 | DEPC-1 | DEPC1 | Prostate cancer antigen 1
Type:
PROTEIN
Mol. Mass.:
33382.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108024
Residue:
286
Sequence:
MEEKRRRARVQGAWAAPVKSQAIAQPATTAKSHLHQKPGQTWKNKEHHLSDREFVFKEPQQVVRRAPEPRVIDREGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLCQDVPWKQRTGIREDITYQQPRLTAWYGELPYTYSRITMEPNPHWHPVLRTLKNRIEENTGHTFNSLLCNLYRNEKDSVDWHSDDEPSLGRCPIIASLSFGATRTFEMRKKPPPEENGDYTYVERVKIPLDHGTLLIMEGATQADWQHRVPKEYHSREPRVNLTFRTVYPDPRGAPW
  
Inhibitor
Name:
BDBM50416768
Synonyms:
CHEMBL5283651
Type:
Small organic molecule
Emp. Form.:
C16H16N2O5S
Mol. Mass.:
348.374
SMILES:
Cc1cc(C)c(c(C)c1)S(=O)(=O)NC(=O)c1cc(ccn1)C(O)=O
Structure:
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