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Target
RNA demethylase ALKBH5
Ligand
BDBM50416762
Substrate
n/a
Meas. Tech.
ChEMBL_2269283
IC50
201300±n/a nM
Citation
 Perry, GS; Das, M; Woon, ECY Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets. J Med Chem 64:16974-17003 (2021) [PubMed]
Target
Name:
RNA demethylase ALKBH5
Synonyms:
1.14.11.53 | ABH5 | ALKB5_HUMAN | ALKBH5 | Alkylated DNA repair protein alkB homolog 5 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5 | OFOXD1 | RNA demethylase ALKBH5
Type:
PROTEIN
Mol. Mass.:
44270.53
Organism:
Homo sapiens
Description:
ChEMBL_109901
Residue:
394
Sequence:
MAAASGYTDLREKLKSMTSRDNYKAGSREAAAAAAAAVAAAAAAAAAAEPYPVSGAKRKYQEDSDPERSDYEEQQLQKEEEARKVKSGIRQMRLFSQDECAKIEARIDEVVSRAEKGLYNEHTVDRAPLRNKYFFGEGYTYGAQLQKRGPGQERLYPPGDVDEIPEWVHQLVIQKLVEHRVIPEGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVSVSFFSDSALCFGCKFQFKPIRVSEPVLSLPVRRGSVTVLSGYAADEITHCIRPQDIKERRAVIILRKTRLDAPRLETKSLSSSVLPPSYASDRLSGNNRDPALKPKRSHRKADPDAAHRPRILEMDKEENRRSVLLPTHRRRGSFSSENYWRKSYESSEDCSEAAGSPARKVKMRRH
  
Inhibitor
Name:
BDBM50416762
Synonyms:
CHEMBL5288180
Type:
Small organic molecule
Emp. Form.:
C14H9F3N2O5S
Mol. Mass.:
374.292
SMILES:
OC(=O)c1ccnc(c1)C(=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F
Structure:
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