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Target
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Ligand
BDBM8739
Substrate
n/a
Meas. Tech.
ChEMBL_2271340
IC50
6440±n/a nM
Citation
 Rana, P; Ghouse, SM; Akunuri, R; Madhavi, YV; Chopra, S; Nanduri, S FabI (enoyl acyl carrier protein reductase) - A potential broad spectrum therapeutic target and its inhibitors. Eur J Med Chem 208:0 (2020) [PubMed]
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Synonyms:
Enoyl - (acyl carrier protein) reductase | Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase | Enoyl-acyl carrier protein reductase (FabI) | FABI_ECOLI | NADH-dependent enoyl-ACP reductase | envM | fabI
Type:
Enzyme
Mol. Mass.:
27861.12
Organism:
Escherichia coli
Description:
n/a
Residue:
262
Sequence:
MGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNELELK
  
Inhibitor
Name:
BDBM8739
Synonyms:
4-(4-methoxyphenyl)-1-[(4-methylphenyl)methyl]-1H-imidazole | Disubstituted imidazole 4
Type:
Small organic molecule
Emp. Form.:
C18H18N2O
Mol. Mass.:
278.3483
SMILES:
COc1ccc(cc1)-c1cn(Cc2ccc(C)cc2)cn1
Structure:
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