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Target
Tumor necrosis factor
Ligand
BDBM50486736
Substrate
n/a
Meas. Tech.
ChEMBL_2271505
IC50
1424±n/a nM
Citation
 Chen, T; Zhu, G; Meng, X; Zhang, X Recent developments of small molecules with anti-inflammatory activities for the treatment of acute lung injury. Eur J Med Chem 207:0 (2020) [PubMed]
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM50486736
Synonyms:
CHEMBL5285518
Type:
Small organic molecule
Emp. Form.:
C25H26F3NO2
Mol. Mass.:
429.4746
SMILES:
CN(C)CCCOc1ccc(\C=C2/CC\C(=C/c3ccccc3C(F)(F)F)C2=O)cc1
Structure:
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