Reaction Details  Report a problem with these data
Target
Bcl-2-like protein 1
Ligand
BDBM473880
Substrate
n/a
Meas. Tech.
ChEMBL_2272931
Ki
2910±n/a nM
Citation
 Chen, L; Chauhan, J; Yap, JL; Goodis, CC; Wilder, PT; Fletcher, S Discovery of  RSC Med Chem 14:103-112 (2023) [PubMed]
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM473880
Synonyms:
5-(4-(4-chloro-3,5- dimethylphenoxy)- N-isobutylphenyl- sulfonamido)-2- hydroxybenzoic acid | US10858316, Compound JY-5-304
Type:
Small organic molecule
Emp. Form.:
C25H26ClNO6S
Mol. Mass.:
503.995
SMILES:
CC(C)CN(c1ccc(O)c(c1)C(O)=O)S(=O)(=O)c1ccc(Oc2cc(C)c(Cl)c(C)c2)cc1
Structure:
Search PDB for entries with ligand similarity: