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Target
Prostaglandin G/H synthase 1
Ligand
BDBM123793
Substrate
n/a
Meas. Tech.
ChEMBL_2273425
IC50
>100000±n/a nM
Citation
 Zhao, Z; Dai, X; Li, C; Wang, X; Tian, J; Feng, Y; Xie, J; Ma, C; Nie, Z; Fan, P; Qian, M; He, X; Wu, S; Zhang, Y; Zheng, X Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect. Eur J Med Chem 186:0 (2020) [PubMed]
Target
Name:
Prostaglandin G/H synthase 1
Synonyms:
COX1 | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_SHEEP | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase)
Type:
Protein
Mol. Mass.:
68868.60
Organism:
Ovis aries (Sheep)
Description:
n/a
Residue:
600
Sequence:
MSRQSISLRFPLLLLLLSPSPVFSADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPEIWTWLRTTLRPSPSFIHFLLTHGRWLWDFVNATFIRDTLMRLVLTVRSNLIPSPPTYNIAHDYISWESFSNVSYYTRILPSVPRDCPTPMDTKGKKQLPDAEFLSRRFLLRRKFIPDPQSTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVEALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRVLRLQPFNEYRKRFGMKPYTSFQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPICSPEYWKASTFGGEVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPRQEDRPGVERPPTEL
  
Inhibitor
Name:
BDBM123793
Synonyms:
4-{[(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol- 4-yl)methyl]amino} benzene sulfonamide (5f)
Type:
Small organic molecule
Emp. Form.:
C17H18N4O3S
Mol. Mass.:
358.415
SMILES:
Cc1[nH]n(-c2ccccc2)c(=O)c1CNc1ccc(cc1)S(N)(=O)=O
Structure:
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