Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM50196598
Substrate
n/a
Meas. Tech.
ChEMBL_422105 (CHEMBL907102)
IC50
6.2±n/a nM
Citation
Marson, CM; Mahadevan, T; Dines, J; Sengmany, S; Morrell, JM; Alao, JP; Joel, SP; Vigushin, DM; Charles Coombes, R Structure-activity relationships of aryloxyalkanoic acid hydroxyamides as potent inhibitors of histone deacetylase. Bioorg Med Chem Lett 17:136-41 (2006) [PubMed] Article
More Info.:
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
Inhibitor
Name:
BDBM50196598
Synonyms:
7-(4-(3-(1H-indol-3-yl)prop-1-en-2-ylamino)phenyl1H-indol-3-yl)prop-1-en-2-ylamino)phenoxy)-N-hydroxyheptanamide | CHEMBL216181
Type:
Small organic molecule
Emp. Form.:
C24H29N3O3
Mol. Mass.:
407.5054
SMILES:
CC(Cc1c[nH]c2ccccc12)=Nc1ccc(OCCCCCCC(=O)NO)cc1 |w:12.14|