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Target
Histone deacetylase 3
Ligand
BDBM50175041
Substrate
n/a
Meas. Tech.
ChEMBL_2287570
IC50
235±n/a nM
Citation
 Bresciani, A; Ontoria, JM; Biancofiore, I; Cellucci, A; Ciammaichella, A; Di Marco, A; Ferrigno, F; Francone, A; Malancona, S; Monteagudo, E; Nizi, E; Pace, P; Ponzi, S; Rossetti, I; Veneziano, M; Summa, V; Harper, S Improved Selective Class I HDAC and Novel Selective HDAC3 Inhibitors: Beyond Hydroxamic Acids and Benzamides. ACS Med Chem Lett 10:481-486 (2019) [PubMed]
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM50175041
Synonyms:
CHEMBL3809034
Type:
Small organic molecule
Emp. Form.:
C25H27N5O2S
Mol. Mass.:
461.579
SMILES:
CNC(=O)CCCCC[C@H](NC(=O)c1cncs1)c1ncc([nH]1)-c1ccc2ccccc2c1 |r|
Structure:
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