Reaction Details  Report a problem with these data
Target
Dual specificity tyrosine-phosphorylation-regulated kinase 4
Ligand
BDBM246383
Substrate
n/a
Meas. Tech.
ChEMBL_2290901
IC50
>10000±n/a nM
Citation
 Lindberg, MF; Deau, E; Arfwedson, J; George, N; George, P; Alfonso, P; Corrionero, A; Meijer, L Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases. J Med Chem 66:4106-4130 (2023) [PubMed]
Target
Name:
Dual specificity tyrosine-phosphorylation-regulated kinase 4
Synonyms:
DYRK4 | DYRK4_HUMAN
Type:
PROTEIN
Mol. Mass.:
59629.96
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1475744
Residue:
520
Sequence:
MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLPQLVDAPKKSEAAVGAEVSMTSPGQSKNFSLKNTNVLPPIV
  
Inhibitor
Name:
BDBM246383
Synonyms:
US9446044, 69
Type:
Small organic molecule
Emp. Form.:
C18H14FN5O2S
Mol. Mass.:
383.399
SMILES:
COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4F)c3c2s1
Structure:
Search PDB for entries with ligand similarity: