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Target
Serine/threonine-protein kinase PLK1
Ligand
BDBM50615026
Substrate
n/a
Meas. Tech.
ChEMBL_2299564
IC50
>25000±n/a nM
Citation
 Guler, S; DiPoto, MC; Crespo, A; Caldwell, R; Doerfel, B; Grossmann, N; Ho, K; Huck, B; Jones, CC; Lan, R; Musil, D; Potnick, J; Schilke, H; Sherer, B; Simon, S; Sirrenberg, C; Zhang, Z; Liu-Bujalski, L Selective Wee1 Inhibitors Led to Antitumor Activity  ACS Med Chem Lett 14:566-576 (2023) [PubMed]
Target
Name:
Serine/threonine-protein kinase PLK1
Synonyms:
PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase
Type:
Serine/threonine-protein kinase
Mol. Mass.:
68277.16
Organism:
Homo sapiens (Human)
Description:
P53350
Residue:
603
Sequence:
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
  
Inhibitor
Name:
BDBM50615026
Synonyms:
CHEMBL5286202
Type:
Small organic molecule
Emp. Form.:
C30H31N7O3
Mol. Mass.:
537.6122
SMILES:
COc1ccccc1-n1n(-c2cccc(n2)C(C)(C)O)c2nc(Nc3ccc4CCN(C)Cc4c3)ncc2c1=O |(7.16,5.15,;6.4,3.82,;7.17,2.49,;8.7,2.49,;9.48,1.17,;8.72,-.16,;7.18,-.16,;6.41,1.16,;4.88,1.16,;3.97,-.1,;4.45,-1.55,;3.41,-2.7,;3.89,-4.15,;5.39,-4.48,;6.42,-3.33,;5.95,-1.87,;7.92,-3.66,;8.95,-2.52,;8.32,-5.15,;9.41,-4.06,;2.5,.38,;1.17,-.38,;-.16,.38,;-1.48,-.39,;-2.81,.37,;-2.81,1.91,;-4.14,2.68,;-5.47,1.91,;-6.8,2.69,;-8.15,1.93,;-8.15,.38,;-9.48,-.38,;-6.81,-.4,;-5.47,.37,;-4.14,-.41,;-.16,1.92,;1.17,2.7,;2.5,1.92,;3.97,2.4,;4.44,3.86,)|
Structure:
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