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Target
Solute carrier organic anion transporter family member 2B1
Ligand
BDBM7461
Substrate
n/a
Meas. Tech.
ChEMBL_2299843
IC50
29000±n/a nM
Citation
 Peng, T; Liu, S; Li, Y; Zhang, H; Hagenbuch, B; Gui, C Investigating the interactions of flavonoids with human OATP2B1: inhibition assay, IC RSC Med Chem 14:890-898 (2023) [PubMed]
Target
Name:
Solute carrier organic anion transporter family member 2B1
Synonyms:
KIAA0880 | OATP-B | OATP-RP2 | OATP2B1
Type:
PROTEIN
Mol. Mass.:
76717.01
Organism:
Homo sapiens
Description:
ChEMBL_104065
Residue:
709
Sequence:
MGPRIGPAGEVPQVPDKETKATMGTENTPGGKASPDPQDVRPSVFHNIKLFVLCHSLLQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALIVFVSYFGSRVHRPRMIGYGAILVALAGLLMTLPHFISEPYRYDNTSPEDMPQDFKASLCLPTTSAPASAPSNGNCSSYTETQHLSVVGIMFVAQTLLGVGGVPIQPFGISYIDDFAHNSNSPLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPRWVGAWWLGFLIAAGAVALAAIPYFFFPKEMPKEKRELQFRRKVLAVTDSPARKGKDSPSKQSPGESTKKQDGLVQIAPNLTVIQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMATFLPKFLERQFSITASYANLLIGCLSFPSVIVGIVVGGVLVKRLHLGPVGCGALCLLGMLLCLFFSLPLFFIGCSSHQIAGITHQTSAHPGLELSPSCMEACSCPLDGFNPVCDPSTRVEYITPCHAGCSSWVVQDALDNSQVFYTNCSCVVEGNPVLAGSCDSTCSHLVVPFLLLVSLGSALACLTHTPSFMLILRGVKKEDKTLAVGIQFMFLRILAWMPSPVIHGSAIDTTCVHWALSCGRRAVCRYYNNDLLRNRFIGLQFFFKTGSVICFALVLAVLRQQDKEARTKESRSSPAVEQQLLVSGPGKKPEDSRV
  
Inhibitor
Name:
BDBM7461
Synonyms:
5,7-dihydroxy-2-phenyl-4H-chromen-4-one | 5,7-dihydroxy-2-phenyl-chromen-4-one | 5,7-dihydroxyflavone | CHEMBL117 | chrysin | cid_5281607
Type:
Small organic molecule
Emp. Form.:
C15H10O4
Mol. Mass.:
254.2375
SMILES:
Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccccc1
Structure:
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