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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM50615358
Substrate
n/a
Meas. Tech.
ChEMBL_2302061
IC50
0.700000±n/a nM
Citation
 Cascioferro, S; Parrino, B; Spanò, V; Carbone, A; Montalbano, A; Barraja, P; Diana, P; Cirrincione, G An overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds. Eur J Med Chem 142:328-375 (2017) [PubMed]
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM50615358
Synonyms:
CHEMBL5282803
Type:
Small organic molecule
Emp. Form.:
C20H24F3N9O4
Mol. Mass.:
511.4577
SMILES:
OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3cnc(NC4CCCCC4N)nn23)c(n1)C(N)=O
Structure:
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