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Target
Histone deacetylase 1
Ligand
BDBM19131
Substrate
n/a
Meas. Tech.
ChEMBL_422016 (CHEMBL908252)
IC50
48±n/a nM
Citation
 Suzuki, T; Hisakawa, S; Itoh, Y; Maruyama, S; Kurotaki, M; Nakagawa, H; Miyata, N Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor. Bioorg Med Chem Lett 17:1558-61 (2007) [PubMed]  Article
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM19131
Synonyms:
CHEMBL419758 | JMC505425 Compound 7 | N-(4-phenyl-1,3-thiazol-2-yl)-7-sulfanylheptanamide | NCH-31
Type:
Small organic molecule
Emp. Form.:
C16H20N2OS2
Mol. Mass.:
320.473
SMILES:
SCCCCCCC(=O)Nc1nc(cs1)-c1ccccc1
Structure:
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