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Target
C-C chemokine receptor type 2
Ligand
BDBM50211501
Substrate
n/a
Meas. Tech.
ChEMBL_436358 (CHEMBL905758)
IC50
>1000±n/a nM
Citation
 Yang, L; Butora, G; Jiao, RX; Pasternak, A; Zhou, C; Parsons, WH; Mills, SG; Vicario, PP; Ayala, JM; Cascieri, MA; MacCoss, M Discovery of 3-piperidinyl-1-cyclopentanecarboxamide as a novel scaffold for highly potent CC chemokine receptor 2 antagonists. J Med Chem 50:2609-11 (2007) [PubMed]  Article
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50211501
Synonyms:
(1R,4R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-methyl-4-[(1R,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide | CHEMBL388164
Type:
Small organic molecule
Emp. Form.:
C30H32F6N2O
Mol. Mass.:
550.5783
SMILES:
CC1C[C@H](C[C@H]1C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)N1CC[C@@]2(C=Cc3ccccc23)[C@@H](C)C1 |w:1.0,c:30|
Structure:
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