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Target
C-C chemokine receptor type 2
Ligand
BDBM50212135
Substrate
n/a
Meas. Tech.
ChEMBL_438766 (CHEMBL889103)
IC50
45±n/a nM
Citation
 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L 3-Amino-1-alkyl-cyclopentane carboxamides as small molecule antagonists of the human and murine CC chemokine receptor 2. Bioorg Med Chem Lett 17:3636-41 (2007) [PubMed]  Article
Target
Name:
C-C chemokine receptor type 2
Synonyms:
CCR2_MOUSE | Ccr2 | Cmkbr2
Type:
PROTEIN
Mol. Mass.:
42795.68
Organism:
Mus musculus
Description:
ChEMBL_1502265
Residue:
373
Sequence:
MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL
  
Inhibitor
Name:
BDBM50212135
Synonyms:
CHEMBL266017 | N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-1-cyclopropyl-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
Type:
Small organic molecule
Emp. Form.:
C32H34F6N2O
Mol. Mass.:
576.6156
SMILES:
C[C@H]1CN(CC[C@]11C=Cc2ccccc12)C1CCC(C1)(C1CC1)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F |w:18.27,15.17,c:8|
Structure:
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