Reaction Details  Report a problem with these data
Target
Steroid hormone receptor ERR1
Ligand
BDBM50171723
Substrate
n/a
Meas. Tech.
ChEMBL_455655 (CHEMBL886438)
IC50
52±n/a nM
Citation
 Vu, AT; Campbell, AN; Harris, HA; Unwalla, RJ; Manas, ES; Mewshaw, RE ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands. Bioorg Med Chem Lett 17:4053-6 (2007) [PubMed]  Article
Target
Name:
Steroid hormone receptor ERR1
Synonyms:
ERR-alpha | ERR1 | ERR1_HUMAN | ESRL1 | ESRRA | Estrogen receptor-like 1 | Estrogen-Related Receptor, alpha | Estrogen-related receptor alpha | NR3B1 | Nuclear receptor subfamily 3 group B member 1 | Steroid hormone receptor ERR1 | Steroid hormone receptor ERR1 alpha | Steroid hormone receptor ERR1/Estrogen-related receptor alpha (ERRa) | von Hippel-Lindau disease tumor suppressor/Steroid hormone receptor ERR1
Type:
PROTEIN
Mol. Mass.:
45508.08
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1499891
Residue:
423
Sequence:
MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAGPGEQGGGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAAPVNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEAMMD
  
Inhibitor
Name:
BDBM50171723
Synonyms:
4-Ethyl-2-(4-hydroxy-phenyl)-quinolin-6-ol | 4-ethyl-2-(4-hydroxyphenyl)quinolin-6-ol | CHEMBL198679
Type:
Small organic molecule
Emp. Form.:
C17H15NO2
Mol. Mass.:
265.3065
SMILES:
CCc1cc(nc2ccc(O)cc12)-c1ccc(O)cc1
Structure:
Search PDB for entries with ligand similarity: