Reaction Details  Report a problem with these data
Target
Tyrosine-protein phosphatase 1
Ligand
BDBM50219479
Substrate
n/a
Meas. Tech.
ChEMBL_437440 (CHEMBL906837)
IC50
86000±n/a nM
Citation
 Shrestha, S; Bhattarai, BR; Lee, KH; Cho, H Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs. Bioorg Med Chem 15:6535-48 (2007) [PubMed]  Article
Target
Name:
Tyrosine-protein phosphatase 1
Synonyms:
PTP1 | PTP1_YEAST | Protein-tyrosine phosphatase 1
Type:
PROTEIN
Mol. Mass.:
38875.77
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_217570
Residue:
335
Sequence:
MAAAPWYIRQRDTDLLGKFKFIQNQEDGRLREATNGTVNSRWSLGVSIEPRNDARNRYVNIMPYERNRVHLKTLSGNDYINASYVKVNVPGQSIEPGYYIATQGPTRKTWDQFWQMCYHNCPLDNIVIVMVTPLVEYNREKCYQYWPRGGVDDTVRIASKWESPGGANDMTQFPSDLKIEFVNVHKVKDYYTVTDIKLTPTDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNSRGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNITERSRHSDRATEEYTRDLIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKYLNSLSVNQ
  
Inhibitor
Name:
BDBM50219479
Synonyms:
3,3'-dicarboxy-2,2'-dihydroxy-5,5'-diphenyldiphenylmethane | 5,5'-methylenebis(4-hydroxybiphenyl-3-carboxylic acid) | CHEMBL228563
Type:
Small organic molecule
Emp. Form.:
C27H20O6
Mol. Mass.:
440.4441
SMILES:
OC(=O)c1cc(cc(Cc2cc(cc(C(O)=O)c2O)-c2ccccc2)c1O)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: