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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM50223568
Substrate
n/a
Meas. Tech.
ChEMBL_458186 (CHEMBL924443)
IC50
790±n/a nM
Citation
 Paruch, K; Dwyer, MP; Alvarez, C; Brown, C; Chan, TY; Doll, RJ; Keertikar, K; Knutson, C; McKittrick, B; Rivera, J; Rossman, R; Tucker, G; Fischmann, TO; Hruza, A; Madison, V; Nomeir, AA; Wang, Y; Lees, E; Parry, D; Sgambellone, N; Seghezzi, W; Schultz, L; Shanahan, F; Wiswell, D; Xu, X; Zhou, Q; James, RA; Paradkar, VM; Park, H; Rokosz, LR; Stauffer, TM; Guzi, TJ Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2. Bioorg Med Chem Lett 17:6220-3 (2007) [PubMed]  Article
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM50223568
Synonyms:
CHEMBL250183 | ethyl 3-bromo-7-(pyridin-3-ylmethylamino)pyrazolo[1,5-a]pyrimidine-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C15H14BrN5O2
Mol. Mass.:
376.208
SMILES:
CCOC(=O)c1cc(NCc2cccnc2)n2ncc(Br)c2n1
Structure:
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