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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50049240
Substrate
n/a
Meas. Tech.
ChEMBL_556513 (CHEMBL956508)
IC50
700±n/a nM
Citation
 Sundriyal, S; Viswanad, B; Bharathy, E; Ramarao, P; Chakraborti, AK; Bharatam, PV New PPARgamma ligands based on 2-hydroxy-1,4-naphthoquinone: computer-aided design, synthesis, and receptor-binding studies. Bioorg Med Chem Lett 18:3192-5 (2008) [PubMed]  Article
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
Nr1c3 | PPARG_RAT | Pparg
Type:
PROTEIN
Mol. Mass.:
57562.54
Organism:
Rattus norvegicus
Description:
ChEMBL_642067
Residue:
505
Sequence:
MGETLGDPPVDPEHGAFADALPMSTSQEITMVDTEMPFWPTNFGISSVDLSVMDDHSHSFDIKPFTTVDFSSISAPHYEDIPFTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNRPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKVLQKMTDLRQIVTEHVQLLHVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50049240
Synonyms:
(+-)-5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione | 5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione | CHEMBL595 | PIOGLITAZONE | PIOGLITAZONE HYDROCHLORIDE
Type:
Small organic molecule
Emp. Form.:
C19H20N2O3S
Mol. Mass.:
356.439
SMILES:
CCc1ccc(CCOc2ccc(Cc3sc(=O)[nH]c3O)cc2)nc1
Structure:
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