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Target
Coagulation factor X
Ligand
BDBM50273187
Substrate
n/a
Meas. Tech.
ChEMBL_510032 (CHEMBL995175)
Ki
100±n/a nM
Citation
 Uchida, M; Okazaki, K; Mukaiyama, H; Isawa, H; Kobayashi, H; Shiohara, H; Muranaka, H; Kai, Y; Kikuchi, N; Takeuchi, H; Yokoyama, K; Tsuji, E; Ozawa, T; Hoyano, Y; Koizumi, T; Misawa, K; Hara, K; Nakano, S; Murakami, Y; Okuno, H Orally active factor Xa inhibitors: investigation of a novel series of 3-amidinophenylsulfonamide derivatives using an amidoxime prodrug strategy. Bioorg Med Chem Lett 18:4682-7 (2008) [PubMed]  Article
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50273187
Synonyms:
4-Hydroxy-3-[2-(4-isopropoxy-phenyl)-ethylsulfamoyl]-benzamidine | CHEMBL513605
Type:
Small organic molecule
Emp. Form.:
C18H23N3O4S
Mol. Mass.:
377.458
SMILES:
CC(C)Oc1ccc(CCNS(=O)(=O)c2cc(ccc2O)C(N)=N)cc1
Structure:
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