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Target
MAP kinase-activated protein kinase 2
Ligand
BDBM23450
Substrate
n/a
Meas. Tech.
ChEMBL_538605 (CHEMBL1027395)
IC50
>100000±n/a nM
Citation
 Constantine, KL; Mueller, L; Metzler, WJ; McDonnell, PA; Todderud, G; Goldfarb, V; Fan, Y; Newitt, JA; Kiefer, SE; Gao, M; Tortolani, D; Vaccaro, W; Tokarski, J Multiple and single binding modes of fragment-like kinase inhibitors revealed by molecular modeling, residue type-selective protonation, and nuclear overhauser effects. J Med Chem 51:6225-9 (2008) [PubMed]  Article
Target
Name:
MAP kinase-activated protein kinase 2
Synonyms:
MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45579.87
Organism:
Homo sapiens (Human)
Description:
P49137
Residue:
400
Sequence:
MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
  
Inhibitor
Name:
BDBM23450
Synonyms:
1-Naphthalenol | 1-Naphthol | CHEMBL122617 | Naphth-1-ol, 9 | alpha-naphthol | naphthalen-1-ol
Type:
Small organic molecule
Emp. Form.:
C10H8O
Mol. Mass.:
144.1699
SMILES:
Oc1cccc2ccccc12
Structure:
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