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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50252781
Substrate
n/a
Meas. Tech.
ChEMBL_539857 (CHEMBL1024853)
IC50
0.6±n/a nM
Citation
 Herberich, B; Cao, GQ; Chakrabarti, PP; Falsey, JR; Pettus, L; Rzasa, RM; Reed, AB; Reichelt, A; Sham, K; Thaman, M; Wurz, RP; Xu, S; Zhang, D; Hsieh, F; Lee, MR; Syed, R; Li, V; Grosfeld, D; Plant, MH; Henkle, B; Sherman, L; Middleton, S; Wong, LM; Tasker, AS Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold. J Med Chem 51:6271-9 (2008) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50252781
Synonyms:
CHEMBL493670 | N-Cyclopropyl-4-methyl-3-(1-(1-methylethoxy)-6-phthalazinyl)benzamide
Type:
Small organic molecule
Emp. Form.:
C22H23N3O2
Mol. Mass.:
361.4369
SMILES:
CC(C)Oc1nncc2cc(ccc12)-c1cc(ccc1C)C(=O)NC1CC1
Structure:
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