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Target
Furin
Ligand
BDBM50279560
Substrate
n/a
Meas. Tech.
ChEMBL_522272 (CHEMBL998935)
Ki
404±n/a nM
Citation
 Worachartcheewan, A; Nantasenamat, C; Naenna, T; Isarankura-Na-Ayudhya, C; Prachayasittikul, V Modeling the activity of furin inhibitors using artificial neural network. Eur J Med Chem 44:1664-73 (2009) [PubMed]  Article
Target
Name:
Furin
Synonyms:
FUR | FURIN | FURIN_HUMAN | Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA | PACE | PCSK3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
86676.01
Organism:
Homo sapiens (Human)
Description:
P09958
Residue:
794
Sequence:
MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQIFGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCLSCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGLSCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL
  
Inhibitor
Name:
BDBM50279560
Synonyms:
CHEMBL448513 | N-{4-[(1S,2S,4R,5R)-2,4-Diguanidino-5-(4-guanidino-naphthalen-1-yloxy)-cyclohexyloxy]-3-guanidino-phenyl}-guanidine
Type:
Small organic molecule
Emp. Form.:
C27H37N15O2
Mol. Mass.:
603.682
SMILES:
[#7]\[#6](-[#7])=[#7]\[#6@H]-1-[#6]-[#6@@H](\[#7]=[#6](\[#7])-[#7])-[#6@@H](-[#6]-[#6@@H]1-[#8]-c1ccc(cc1\[#7]=[#6](\[#7])-[#7])\[#7]=[#6](\[#7])-[#7])-[#8]-c1ccc(\[#7]=[#6](\[#7])-[#7])c2ccccc12 |r|
Structure:
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