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Target
Sodium- and chloride-dependent glycine transporter 2
Ligand
BDBM50248128
Substrate
n/a
Meas. Tech.
ChEMBL_543462 (CHEMBL1016010)
IC50
>30000±n/a nM
Citation
 Wolkenberg, SE; Zhao, Z; Wisnoski, DD; Leister, WH; O'Brien, J; Lemaire, W; Williams, DL; Jacobson, MA; Sur, C; Kinney, GG; Pettibone, DJ; Tiller, PR; Smith, S; Gibson, C; Ma, BK; Polsky-Fisher, SL; Lindsley, CW; Hartman, GD Discovery of GlyT1 inhibitors with improved pharmacokinetic properties. Bioorg Med Chem Lett 19:1492-5 (2009) [PubMed]  Article
Target
Name:
Sodium- and chloride-dependent glycine transporter 2
Synonyms:
GLYT2 | Glycine transporter 2 | NET1 | SC6A5_HUMAN | SLC6A5 | Sodium- and chloride-dependent glycine transporter 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
87438.56
Organism:
Homo sapiens (Human)
Description:
Glycine-2-transporter 0 HUMAN::Q9Y345
Residue:
797
Sequence:
MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQTFQSADARACEAERPGVGSCKLSSPRAQAASAALRDLREAQGAQASPPPGSSGPGNALHCKIPFLRGPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVVLATDGITSVLPGSVATVATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTSSLGLKLPVKDLELGTQC
  
Inhibitor
Name:
BDBM50248128
Synonyms:
2,4-dichloro-N-((1-(2-fluoropropylsulfonyl)-4-(pyridin-2-yl)piperidin-4-yl)methyl)benzamide | CHEMBL461986
Type:
Small organic molecule
Emp. Form.:
C21H24Cl2FN3O3S
Mol. Mass.:
488.403
SMILES:
CC(F)CS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)c1ccccn1
Structure:
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