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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50259004
Substrate
n/a
Meas. Tech.
ChEMBL_499620 (CHEMBL972418)
Ki
0.18±n/a nM
Citation
 Grosse Maestrup, E; Wiese, C; Schepmann, D; Hiller, A; Fischer, S; Scheunemann, M; Brust, P; Wünsch, B Synthesis of spirocyclic sigma1 receptor ligands as potential PET radiotracers, structure-affinity relationships and in vitro metabolic stability. Bioorg Med Chem 17:3630-41 (2009) [PubMed]  Article
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50259004
Synonyms:
1'-[4-Fluorobenzyl]-3H-spiro[[2]benzofuran-1,4'piperidine] | CHEMBL466289
Type:
Small organic molecule
Emp. Form.:
C19H20FNO
Mol. Mass.:
297.3666
SMILES:
Fc1ccc(CN2CCC3(CC2)OCc2ccccc32)cc1
Structure:
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