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Target
Type-1 angiotensin II receptor
Ligand
BDBM50280908
Substrate
n/a
Meas. Tech.
ChEBML_36936
IC50
5100±n/a nM
Citation
 Wu, MT; Ikeler, TJ; Ashton, WT; Chang, RS; Lotti, VJ; Greenlee, WJ Synthesis and structure-activity relationships of a novel series of non-peptide AT2-selective angiotensin II receptor antagonists Bioorg Med Chem Lett 3:2023-2028 (1993)    Article
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41009.15
Organism:
RABBIT
Description:
ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:
359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
  
Inhibitor
Name:
BDBM50280908
Synonyms:
1-[3-chlorophenyl(phenyl)carbamoyl]-4-dipentylcarbamoyl-(2S)-hexahydro-2-pyrazinecarboxylic acid | CHEMBL60071
Type:
Small organic molecule
Emp. Form.:
C29H39ClN4O4
Mol. Mass.:
543.097
SMILES:
CCCCCN(CCCCC)C(=O)N1CCN([C@@H](C1)C(O)=O)C(=O)N(c1ccccc1)c1cccc(Cl)c1
Structure:
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