Reaction Details  Report a problem with these data
Target
Type-2 angiotensin II receptor
Ligand
BDBM50282278
Substrate
n/a
Meas. Tech.
ChEMBL_35438 (CHEMBL643798)
IC50
400±n/a nM
Citation
 Mantlo, NB; Kim, D; Ondeyka, D; Chang, RS; Kivlighn, SD; Siegl, PK; Greenlee, WJ Imidazo[4,5-b]pyridine-based AT1 / AT2 angiotensin II receptor antagonists Bioorg Med Chem Lett 4:17-22 (1994)    Article
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41346.62
Organism:
RAT
Description:
Angiotensin II AT2 0 0::P35351
Residue:
363
Sequence:
MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
  
Inhibitor
Name:
BDBM50282278
Synonyms:
CHEMBL307757 | N-Butyl-N-{2-butyl-7-methyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridin-6-yl}-benzamide
Type:
Small organic molecule
Emp. Form.:
C36H38N8O
Mol. Mass.:
598.7399
SMILES:
CCCCN(C(=O)c1ccccc1)c1cnc2n(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c(CCCC)nc2c1C
Structure:
Search PDB for entries with ligand similarity: